Nanotopography presents an effective physical approach for biomaterial cell manipulation
mediated through material-extracellular matrix interactions. The extracellular matrix that …

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs),
including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK …

Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …

Signaling pathways involved in oxidative stress-induced inhibition of osteoblast
differentiation are not known. We showed in this report that H2O2 (0.1–0.2 mM)-induced …

Bone tissue engineering holds great promise for the regeneration of damaged or severe
bone defects. However, several challenges hinder its translation into clinical practice. To …

The extracellular signal–regulated kinase (ERK)–mitogen-activated protein kinase (MAPK)
pathway provides a major link between the cell surface and nucleus to control proliferation …

Closely related signals often lead to very different cellular outcomes. We found that the
differentiation of human mesenchymal stem cells into bone-forming cells is stimulated by …

We investigated the direct effects of changes in free ionized extracellular calcium
concentrations ([Ca2+] o) on osteoblast function and the involvement of the calcium-sensing …

Chronic kidney disease is highly prevalent worldwide. The decline of renal function is
associated with inadequate removal of a variety of uremic toxins that exert detrimental …

This study sought to assess the role of several signaling pathways in the fluid flow shear
stress-induced proliferation and differentiation of normal human osteoblasts. We evaluated …