The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …

Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with
klotho, a longevity factor, could enhance cognition in human-relevant models such as in …

Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …