Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

Epilepsy is a disease characterized by abnormal brain activity and a predisposition to
generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and …

Severe myoclonic epilepsy of infancy (SMEI) is a rare disorder that occurs in isolated
patients. The disease is characterized by generalized tonic, clonic, and tonic-clonic seizures …

Voltage-gated sodium channels (NaV) are critical for initiation of action potentials.
Heterozygous loss-of-function mutations in NaV1. 1 channels cause severe myoclonic …

OBJECTIVE: De novo mutations of the gene sodium channel 1α (SCN1A) are the major
cause of Dravet syndrome, an infantile epileptic encephalopathy. US incidence of DS has …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Mutations in a number of genes encoding voltage‐gated sodium channels cause a variety of
epilepsy syndromes in humans, including genetic (generalized) epilepsy with febrile …

Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a
multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and …

Among the nine subtypes of human voltage-gated sodium (Nav) channels, the brain and
cardiac isoforms, Nav1. 1 and Nav1. 5, each carry more than 400 missense mutations …

Pyrethroid insecticides have been used for more than 40 years and account for 25% of the
worldwide insecticide market. Although their acute neurotoxicity to adults has been well …