The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Chagas disease (CD) is a vector-borne Neglected Zoonotic Disease (NZD) caused by a
flagellate protozoan, Trypanosoma cruzi, that affects various mammalian species across …

The second World Neglected Tropical Diseases (NTDs) Day was celebrated on 30 January
2021. To mark the occasion, the World Health Organization (WHO) launched its roadmap for …

Despite medical progress, more than a billion people still suffer daily from parasitic
infections. Vaccination is recognized as one of the most sustainable options to control …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a highly overlooked
parasitic infection within the United States. It affects an estimated 300,000 individuals, often …

Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …

Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …

Chagas disease is currently endemic to 21 Latin-American countries and has also become a
global concern because of globalization and mass migration of chronically infected …

Tc24 is a Trypanosoma cruzi-derived flagellar protein that, when formulated with a TLR-4
agonist adjuvant, induces a balanced immune response in mice, elevating IgG2a antibody …

Chagas disease (CD) treatment and vaccine development are critical due to the significant
health burden caused by the disease, especially in Latin America. Current treatments …