Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …

Research on human cerebellar development and disease has been hampered by the need
for a human cell-based system that recapitulates the human cerebellum's cellular diversity …

Medulloblastoma (MB) is the most common malignant childhood brain tumour,, yet the origin
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …

Human cerebellar development is orchestrated by molecular regulatory networks to achieve
cytoarchitecture and coordinate motor and cognitive functions. Here, we combined single …

OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is
amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 …

Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-
altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs) …

Medulloblastoma is the most common pediatric malignant brain tumor composed of four
molecular subgroups. Recent intensive genomics has greatly contributed to our …