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Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
[HTML][HTML] Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis …
The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy
but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber …
but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber …
The role of PIEZO ion channels in the musculoskeletal system
PIEZO1 and PIEZO2 are mechanosensitive cation channels that are highly expressed in
numerous tissues throughout the body and exhibit diverse, cell-specific functions in multiple …
numerous tissues throughout the body and exhibit diverse, cell-specific functions in multiple …
[HTML][HTML] OA foundations–experimental models of osteoarthritis
Osteoarthritis (OA) is increasingly recognised as a disease of diverse phenotypes with
variable clinical presentation, progression, and response to therapeutic intervention. This …
variable clinical presentation, progression, and response to therapeutic intervention. This …
Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis
Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk
among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) …
among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) …
[HTML][HTML] Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats
Present research explored the anti-obesity effect of Moringa olifera seed oil extract and
lycopene (LYC). Forty eight male Sprauge Dawely rats were divided equally into 6 groups …
lycopene (LYC). Forty eight male Sprauge Dawely rats were divided equally into 6 groups …
[HTML][HTML] Osteoarthritis as an umbrella term for different subsets of humans undergoing joint degeneration: The need to address the differences to develop effective …
DA Hart - International Journal of Molecular Sciences, 2022 - mdpi.com
Osteoarthritis (OA) of joints such as the knee and hip are very prevalent, and the number of
individuals affected is expected to continue to rise. Currently, conservative treatments after …
individuals affected is expected to continue to rise. Currently, conservative treatments after …
An update on the association between metabolic syndrome and osteoarthritis and on the potential role of leptin in osteoarthritis
YH Gao, CW Zhao, B Liu, N Dong, L Ding, YR Li… - Cytokine, 2020 - Elsevier
Metabolic syndrome (MetS) has been associated with osteoarthritis (OA). Leptin, which is
one of the markers of MetS, has been associated with OA pathophysiology. This study aimed …
one of the markers of MetS, has been associated with OA pathophysiology. This study aimed …
Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately
leading to disability and decrease of quality of life. Two key mechanisms have been …
leading to disability and decrease of quality of life. Two key mechanisms have been …
Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats
Introduction Obesity is a multifactorial chronic inflammatory disease. Consumption of high
energy density (HED) diets is associated with hyperphagia, increased body weight and body …
energy density (HED) diets is associated with hyperphagia, increased body weight and body …