Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
COVID-19 therapeutics: Challenges and directions for the future
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …
[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
[HTML][HTML] A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
It is not well understood why diabetic individuals are more prone to develop severe COVID-
19. To this, we here established a human kidney organoid model promoting early hallmarks …
19. To this, we here established a human kidney organoid model promoting early hallmarks …
An overview on the treatments and prevention against COVID-19
Y Panahi, AM Gorabi, S Talaei, F Beiraghdar… - Virology Journal, 2023 - Springer
Background The coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …
Clinical grade ACE2 as a universal agent to block SARS‐CoV‐2 variants
The recent emergence of multiple SARS‐CoV‐2 variants has caused considerable concern
due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It …
due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It …
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
Enzyme therapy: current challenges and future perspectives
M de la Fuente, L Lombardero… - International Journal of …, 2021 - mdpi.com
In recent years, enzymes have risen as promising therapeutic tools for different pathologies,
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …
Investigation of the Effects of Covid-19 on Different Organs of the Body
D Birman - Eurasian Journal of Chemical, Medicinal and …, 2023 - ejcmpr.com
This study investigated the effects of Covid-19 on body postures. Specialists around the
world are now conducting clinical trials and research to understand why some patients …
world are now conducting clinical trials and research to understand why some patients …