Primary somatosensory neurons convey salient information about our external environment
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …

Neuronal growth cones navigate over long distances along specific pathways to find their
correct targets. The mechanisms and molecules that direct this pathfinding are the topics of …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

The semaphorin family contains a large number of phylogenetically conserved proteins and
includes several members that have been shown to function in repulsive axon guidance …

Extending axons in the develo** nervous system are guided to their targets through the
coordinate actions of attractive and repulsive guidance cues. The semaphorin family of …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Astrocytes, the most abundant cells in the central nervous system, promote synapse
formation and help to refine neural connectivity. Although they are allocated to spatially …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and …

COLLAPSIN1, a member of the newly recognized semaphorin family2á¤-4, contributes to
axonal pathfinding during neural development by inhibiting growth cone extension1á¤-5 …

Semaphorins are a large family of secreted and transmembrane proteins, several of which
are implicated in repulsive axon guidance. Neuropilin (neuropilin-1) was recently identified …