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The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …
tuberculosis remains out of control in several parts of the world including Africa and Asia …
Solid-state NMR investigations of extracellular matrixes and cell walls of algae, bacteria, fungi, and plants
Extracellular matrixes (ECMs), such as the cell walls and biofilms, are important for
supporting cell integrity and function and regulating intercellular communication. These …
supporting cell integrity and function and regulating intercellular communication. These …
CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
S Li, NC Poulton, JS Chang, ZA Azadian… - Nature …, 2022 - nature.com
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …
Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen
A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …
remains one of the leading causes of mortality across the world. There is an urgent …
Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines
R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …
The complex glycans in the glycocalyx are involved in various biological events, such as …
The Gram-positive bacterial cell wall
M Rohde - Microbiology spectrum, 2019 - journals.asm.org
The chapter about the Gram-positive bacterial cell wall gives a brief historical background
on the discovery of Gram-positive cell walls and their constituents and microscopic methods …
on the discovery of Gram-positive cell walls and their constituents and microscopic methods …
Crystal structures of membrane transporter MmpL3, an anti-TB drug target
Despite intensive efforts to discover highly effective treatments to eradicate tuberculosis
(TB), it remains as a major threat to global human health. For this reason, new TB drugs …
(TB), it remains as a major threat to global human health. For this reason, new TB drugs …
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …
leading cause of death from an infectious disease, with a mortality rate of over a million …
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol
L Zhang, Y Zhao, Y Gao, L Wu, R Gao, Q Zhang… - Science, 2020 - science.org
The arabinosyltransferases EmbA, EmbB, and EmbC are involved in Mycobacterium
tuberculosis cell wall synthesis and are recognized as targets for the anti-tuberculosis drug …
tuberculosis cell wall synthesis and are recognized as targets for the anti-tuberculosis drug …
The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis
R Kalscheuer, A Palacios, I Anso, J Cifuente… - Biochemical …, 2019 - portlandpress.com
Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …