The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Solid-state NMR investigations of extracellular matrixes and cell walls of algae, bacteria, fungi, and plants

N Ghassemi, A Poulhazan, F Deligey… - Chemical …, 2021 - ACS Publications
Extracellular matrixes (ECMs), such as the cell walls and biofilms, are important for
supporting cell integrity and function and regulating intercellular communication. These …

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

S Li, NC Poulton, JS Chang, ZA Azadian… - Nature …, 2022 - nature.com
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …

Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen

A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines

R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

The Gram-positive bacterial cell wall

M Rohde - Microbiology spectrum, 2019 - journals.asm.org
The chapter about the Gram-positive bacterial cell wall gives a brief historical background
on the discovery of Gram-positive cell walls and their constituents and microscopic methods …

Crystal structures of membrane transporter MmpL3, an anti-TB drug target

B Zhang, J Li, X Yang, L Wu, J Zhang, Y Yang, Y Zhao… - Cell, 2019 - cell.com
Despite intensive efforts to discover highly effective treatments to eradicate tuberculosis
(TB), it remains as a major threat to global human health. For this reason, new TB drugs …

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol

L Zhang, Y Zhao, Y Gao, L Wu, R Gao, Q Zhang… - Science, 2020 - science.org
The arabinosyltransferases EmbA, EmbB, and EmbC are involved in Mycobacterium
tuberculosis cell wall synthesis and are recognized as targets for the anti-tuberculosis drug …

The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis

R Kalscheuer, A Palacios, I Anso, J Cifuente… - Biochemical …, 2019 - portlandpress.com
Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …