An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to
overcome environmental insults and respond to physiological cues. The mitochondrial …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

Eukaryotic cells contain numerous iron-requiring proteins such as iron-sulfur (Fe-S) cluster
proteins, hemoproteins and ribonucleotide reductases (RNRs). These proteins utilize iron as …

Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and
physiological processes,–. Haem binding proteins are present in almost all cellular …

Heme is an essential cofactor and signaling molecule. Heme acquisition by proteins and
heme signaling are ultimately reliant on the ability to mobilize labile heme (LH). However …

Chloroplast signals regulate hundreds of nuclear genes during development and in
response to stress, but little is known of the signals or signal transduction mechanisms of …

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for
virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed …

The appearance of heme, an organic ring surrounding an iron atom, in evolution forever
changed the efficiency with which organisms were able to generate energy, utilize gasses …