Next generation deep sequencing and vaccine design: today and tomorrow
Next generation sequencing (NGS) technologies have redefined the modus operandi in
both human and microbial genetics research, allowing the unprecedented generation of …
both human and microbial genetics research, allowing the unprecedented generation of …
Persistent low-level replication of SIVΔnef drives maturation of antibody and CD8 T cell responses to induce protective immunity against vaginal SIV infection
S Adnan, RK Reeves, J Gillis, FE Wong, Y Yu… - PLoS …, 2016 - journals.plos.org
Defining the correlates of immune protection conferred by SIVΔnef, the most effective
vaccine against SIV challenge, could enable the design of a protective vaccine against HIV …
vaccine against SIV challenge, could enable the design of a protective vaccine against HIV …
CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection
S Adnan, AD Colantonio, Y Yu, J Gillis, FE Wong… - PLoS …, 2015 - journals.plos.org
The live attenuated simian immunodeficiency virus (LASIV) vaccine SIVΔnef is one of the
most effective vaccines in inducing protection against wild-type lentiviral challenge, yet little …
most effective vaccines in inducing protection against wild-type lentiviral challenge, yet little …
Acute-phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus
M Harris, CM Burns, EA Becker, AT Braasch… - Journal of …, 2013 - Am Soc Microbiol
The overall CD8 T cell response to human/simian immunodeficiency virus (HIV/SIV) targets
a collection of discrete epitope specificities. Some of these epitope-specific CD8 T cells …
a collection of discrete epitope specificities. Some of these epitope-specific CD8 T cells …
Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling
JM Billingsley, PA Rajakumar, MA Connole… - PLoS …, 2015 - journals.plos.org
The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated
macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in …
macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in …
Diverse peptide presentation of rhesus macaque major histocompatibility complex class I mamu-a* 02 revealed by two peptide complex structures and insights into …
Major histocompatibility complex class I (MHC I)-restricted CD8+ T-cell responses play a
pivotal role in anti-human immunodeficiency virus (HIV) immunity and the control of viremia …
pivotal role in anti-human immunodeficiency virus (HIV) immunity and the control of viremia …
Virus adaptation and selection following challenge of animals vaccinated against classical swine fever virus
Vaccines against classical swine fever have proven very effective in protecting pigs from this
deadly disease. However, little is known about how vaccination impacts the selective …
deadly disease. However, little is known about how vaccination impacts the selective …
Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B* 17: insights into immune protection from simian …
Y Wu, F Gao, J Liu, J Qi, E Gostick… - The Journal of …, 2011 - journals.aai.org
The MHC class I molecule Mamu-B* 17 has been associated with elite control of SIV
infection in rhesus macaques, akin to the protective effects described for HLA-B* 57 in HIV …
infection in rhesus macaques, akin to the protective effects described for HLA-B* 57 in HIV …
Adoptive transfer of lymphocytes isolated from simian immunodeficiency virus SIVmac239Δnef-vaccinated macaques does not affect acute-phase viral loads but may …
JM Greene, JJ Lhost, PJ Hines, M Scarlotta… - Journal of …, 2013 - Am Soc Microbiol
The live attenuated simian immunodeficiency virus (SIV) SIVmac239Δnef is the most
effective SIV/human immunodeficiency virus (HIV) vaccine in preclinical testing. An …
effective SIV/human immunodeficiency virus (HIV) vaccine in preclinical testing. An …
High-throughput sequencing and vaccine design.
F Luciani - Revue scientifique et technique (International Office of …, 2016 - europepmc.org
Next-generation sequencing (NGS) technologies have reshaped genome research. The
resulting increase in sequencing depth and resolution has led to an unprecedented level of …
resulting increase in sequencing depth and resolution has led to an unprecedented level of …