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Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis
C Costa, JN Moreira, MH Amaral, JMS Lobo… - Journal of Controlled …, 2019 - Elsevier
Epileptic seizures and anxiety crisis are severe conditions that require fast and effective
treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited …
treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited …
Strategies facilitating the permeation of nanoparticles through blood-brain barrier: An insight towards the development of brain-targeted drug delivery system
The blood-brain barrier (BBB) is a membrane barrier considered one of the most crucial
protective architectures in the central nervous system (CNS). Its presence acts as a hurdle …
protective architectures in the central nervous system (CNS). Its presence acts as a hurdle …
[HTML][HTML] Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain
Epilepsy is considered as a common and diverse set of chronic neurological disorders and
its symptoms can be controlled by antiepileptic drugs (AEDs). The presence of p …
its symptoms can be controlled by antiepileptic drugs (AEDs). The presence of p …
[HTML][HTML] Epilepsy disease and nose-to-brain delivery of polymeric nanoparticles: an overview
Epilepsy is the fourth most common global neurological problem, which can be considered a
spectrum disorder because of its various causes, seizure types, its ability to vary in severity …
spectrum disorder because of its various causes, seizure types, its ability to vary in severity …
A review of intranasal formulations for the treatment of seizure emergencies
Epileptic seizure emergencies are life-threatening conditions, which in their most severe
form, status epilepticus, have a high mortality rate if not quickly terminated. Treatment …
form, status epilepticus, have a high mortality rate if not quickly terminated. Treatment …
[HTML][HTML] Solid lipid nanoparticles for nose to brain delivery of haloperidol: in vitro drug release and pharmacokinetics evaluation
In the present study, haloperidol (HP)-loaded solid lipid nanoparticles (SLNs) were prepared
to enhance the uptake of HP to brain via intranasal (in) delivery. SLNs were prepared by a …
to enhance the uptake of HP to brain via intranasal (in) delivery. SLNs were prepared by a …
Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is the most common
autosomal dominantly inherited ataxia worldwide. It is caused by an over-repetition of the …
autosomal dominantly inherited ataxia worldwide. It is caused by an over-repetition of the …
PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization
Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of
neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been …
neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been …
Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study
Mirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low
bioavailability, which is only 50%, in spite of its rapid absorption when orally administered …
bioavailability, which is only 50%, in spite of its rapid absorption when orally administered …
Resveratrol anchored nanostructured lipid carrier loaded in situ gel via nasal route: Formulation, optimization and in vivo characterization
The purpose of the present study was to formulate resveratrol loaded nanostructured lipid
carrier based in situ gel for intranasal administration. Resveratrol loaded lipid carrier was …
carrier based in situ gel for intranasal administration. Resveratrol loaded lipid carrier was …