[HTML][HTML] Potential targeting mechanisms for bone-directed therapies
Bone development is characterized by complex regulation mechanisms, including signal
transduction and transcription factor-related pathways, glycobiological processes, cellular …
transduction and transcription factor-related pathways, glycobiological processes, cellular …
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use
Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …
Bisphosphonates: Synthesis, structures, properties, medical and industrial applications
This review is a first attempt to overview both medical and industrial applications of
bisphosphonates (BPs) at once, with an emphasis on structure–property relationships. The …
bisphosphonates (BPs) at once, with an emphasis on structure–property relationships. The …
Geranyl Diphosphate Synthase (CrtE) Inhibition Using Alendronate Enhances Isoprene Production in Recombinant Synechococcus elongatus UTEX 2973: A Step …
A hemiterpene, isoprene, is commercially produced from crude oil refining processes. As a
result of fossil fuel depletion, isoprene production process development is gaining attention …
result of fossil fuel depletion, isoprene production process development is gaining attention …
A retrospective case series on bisphosphonate related osteonecrosis of the jaw in 20 cats
SL Hatunen, JG Anderson, CM Bell… - Frontiers in Veterinary …, 2024 - frontiersin.org
Introduction This retrospective study highlights the salient aspects of a series of feline
patients affected with bisphosphonate related osteonecrosis of the jaw. Though more …
patients affected with bisphosphonate related osteonecrosis of the jaw. Though more …
Synergistic anti-tumor effect of simvastatin combined to chemotherapy in osteosarcoma
A Mangelinck, N Habel, A Mohr, N Gaspar… - Cancers, 2021 - mdpi.com
Simple Summary Osteosarcoma is the most common form of primary solid bone malignancy,
with the highest incidence in adolescence. The therapeutic management includes surgical …
with the highest incidence in adolescence. The therapeutic management includes surgical …
Clodronate
Two early observations about the first generation bisphosphonate, clodronate, suggested
that it would likely have clinical utility; specifically, it was a more potent anti-resorptive but a …
that it would likely have clinical utility; specifically, it was a more potent anti-resorptive but a …
Is the use of bisphosphonates putting horses at risk? An osteoclast perspective
FB Vergara-Hernandez, BD Nielsen, AC Colbath - Animals, 2022 - mdpi.com
Simple Summary Bisphosphonates are a group of drugs that intervene in the bone
resorption process, producing cellular death of osteoclasts. These drugs are used for …
resorption process, producing cellular death of osteoclasts. These drugs are used for …
Nanocarriers in Veterinary Medicine: A Challenge for Improving Osteosarcoma Conventional Treatments
S Sapino, G Chindamo, D Chirio, S Morel, E Peira… - Nanomaterials, 2022 - mdpi.com
In recent years, several nanocarrier-based drug delivery systems, such as polymeric
nanoparticles, solid lipid nanoparticles, metallic nanoparticles, liposomes, and others, have …
nanoparticles, solid lipid nanoparticles, metallic nanoparticles, liposomes, and others, have …
Improving osteosarcoma treatment: comparative oncology in action
L Tarone, K Mareschi, E Tirtei, D Giacobino… - Life, 2022 - mdpi.com
Osteosarcoma (OSA) is the most common pediatric malignant bone tumor. Although surgery
together with neoadjuvant/adjuvant chemotherapy has improved survival for localized OSA …
together with neoadjuvant/adjuvant chemotherapy has improved survival for localized OSA …