Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …

It is now well accepted that plasma cells can become long-lived (memory) plasma cells and
secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this …

There is growing interest in the complex relationship between the nervous and immune
systems and how its alteration can affect homeostasis and result in the development of …

Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a TH2-dominated
immune response associated with increased serum IgE levels in response to inhaled …

Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative
diseases and traumatic injuries. However, MSC engraftment is not always successful and …

After approximately 130 years since their discovery as rare granulocytes that circulate in
blood, basophils are just now gaining respect as significant contributors in the pathogenesis …

In addition to their well-known roles in the nervous system, there is increasing recognition
that neurotrophins such as brain derived neurotrophic factor (BDNF) as well as their …

Long-lived plasma cells survive in a protected microenvironment for years or even a lifetime
and provide humoral memory by establishing persistent Ab titers. Long-lived autoreactive …

Neurotrophins (NTs) are a family of growth factors that are well-known in the nervous
system. There is increasing recognition that NTs (nerve growth factor, brain-derived …