Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases

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DNA-binding proteins and uses thereof

PD Gregory, JC Miller, D Paschon, EJ Rebar… - US Patent …, 2013 - Google Patents
2011-08-17 Assigned to SANGAMO BIOSCIENCES, INC. reassignment SANGAMO
BIOSCIENCES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
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TAL effector-mediated DNA modification

DF Voytas, A Bogdanove, F Zhang, M Christian… - US Patent …, 2013 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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T cell modifying compounds and uses thereof

PD Gregory, MC Holmes - US Patent 9,597,357, 2017 - Google Patents
5,356,802 A 10/1994 Chandrasegaran 5,420,032 A 5, 1995 Marshall et al. 5,436,150 A 7,
1995 Chandrasegaran 5.487, 994 A 1/1996 Chandrasegaran 5,789,538 A 8, 1998 Rebar et …
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TAL effector-mediated DNA modification

DF Voytas, AJ Bogdanove, F Zhang - US Patent 8,440,431, 2013 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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Tal effector-mediated DNA modification

DF Voytas, AJ Bogdanove, F Zhang - US Patent 8,440,432, 2013 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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TAL effector-mediated DNA modification

DF Voytas, AJ Bogdanove, F Zhang - US Patent 8,450,471, 2013 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components

J Dahlman, RJ PLATT, DG Anderson, R Langer… - 2015 - Google Patents
WO2015089419A2 - Delivery, use and therapeutic applications of the crispr-cas systems
and compositions for targeting disorders and diseases using particle delivery components …
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T cell receptor-deficient T cell compositions

CL Sentman - US Patent 9,181,527, 2015 - Google Patents
The invention is directed to modified T cells, methods of making and using isolated, modified
T cells, and methods of using these isolated, modified T cells to address diseases and …
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Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells

F Zhang, M HEDENREICH, L Swiech - 2014 - Google Patents
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CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA

LJN Cooper, H Torikai - US Patent 10,391,126, 2019 - Google Patents
The present invention concerns methods and compositions for immunotherapy employing a
modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric …
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