Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of
numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the …

Both occupational and environmental exposure to particles is associated with an increased
risk of lung cancer. Particles are thought to impact on genotoxicity as well as on cell …

Conclusions The lung interfaces with the environment across a continuous and
heterogeneous epithelium. The proximal conducting airways are lined with a …

Clara cell protein (CC16) is a 15.8‐kDa homodimeric protein secreted in large amounts in
airways by the non‐ciliated bronchiolar Clara cells. This protein increasingly appears to …

Background Low concentrations of the anti-inflammatory protein CC16 (approved symbol
SCGB1A1) in serum have been associated with accelerated decline in forced expiratory …

Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name
SCGB1A1), is one of the most abundant proteins in the lung, primarily produced by club …

Acute lung injury (ALI) is still associated with high mortality. Growing evidence suggests that
Club Cell Protein 16 (CC16) plays a protective role against ALI. However, the doses of …

Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted
protein that has been extensively studied from the standpoint of its structure and molecular …

Clinical detection of silicosis is currently dependent on radiological and lung function
abnormalities, both late manifestations of disease. Markers of prediction and early detection …

Cigarette smoking has diverse effects on the structure and function of the lung. Smoking
appears to reduce the levels of Clara cell 10 kDa protein (CC10) in the alveolar lining fluid …