Ribosome-associated quality-control mechanisms from bacteria to humans
Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …
produced by interrupted translation. Central players in RQC are the human ribosome-and …
Translation‐coupled mRNA quality control mechanisms
L Monaghan, D Longman, JF Cáceres - The EMBO Journal, 2023 - embopress.org
Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
Programmed ribosomal frameshifting is a key event during translation of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the …
Translational control of stem cell function
Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …
cell types. Research has focused primarily on how these processes are regulated at a …
Structure of Gcn1 bound to stalled and colliding 80S ribosomes
AA Pochopien, B Beckert… - Proceedings of the …, 2021 - National Acad Sciences
The Gcn pathway is conserved in all eukaryotes, including mammals such as humans,
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
The ribotoxic stress response (RSR) is a signaling pathway in which the p38-and c-Jun N-
terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) …
terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) …
Translation and mRNA stability control
Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …
post-transcriptional process that profoundly impact protein production in a cell. While it is …
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
G Snieckute, AV Genzor, AC Vind, L Ryder, M Stoneley… - Cell Metabolism, 2022 - cell.com
Impairment of translation can lead to collisions of ribosomes, which constitute an activation
platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic …
platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic …
Ribosomal stress-surveillance: three pathways is a magic number
Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …
Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly (dA: dT)
JY Zhou, MK Sarkar, K Okamura… - Proceedings of the …, 2023 - National Acad Sciences
The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …