Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on individuals
with the disease, which can include a range of symptoms (breathlessness, cough, sputum …

Skeletal muscle dysfunction occurs in patients with chronic obstructive pulmonary disease
(COPD) and affects both ventilatory and nonventilatory muscle groups. It represents a very …

This European Respiratory Society (ERS) statement provides a comprehensive overview on
physical activity in patients with chronic obstructive pulmonary disease (COPD). A …

Sarcopenia and frailty are geriatric syndromes characterized by multisystem decline, which
are related to and reflected by markers of skeletal muscle dysfunction. In older people …

A gap exists between guidelines and real-world clinical practice for the management and
treatment of chronic obstructive pulmonary disease (COPD). Although this has narrowed in …

Background Age-related loss of muscle, sarcopenia, is recognised as a clinical syndrome
with multiple contributing factors. International European Working Group on Sarcopenia in …

Rationale Reduced physical activity (PA) in patients with COPD is associated with a poor
prognosis. Increasing PA is a key therapeutic target, but thus far few strategies have been …

Rationale: Little is known about the role of physical activity in the course of chronic
obstructive pulmonary disease (COPD). Objectives: To assess changes in physical activity in …

COPD is associated with a progressive loss of muscle mass and function. However, there is
an unmet need to define and standardise methods to estimate the prevalence of sarcopenia …