Non-coding RNAs in human disease
M Esteller - Nature reviews genetics, 2011 - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …
context of the widespread disruption of microRNA (miRNA) expression and function that is …
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease
E Mogilyansky, I Rigoutsos - Cell Death & Differentiation, 2013 - nature.com
Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …
cluster and its members has been increasing steadily and the number of publications has …
The role of microRNAs in the pathophysiology of human central nervous system: a focus on neurodegenerative diseases
Abstract microRNAs (miRNAs) are suggested to play substantial roles in regulating the
development and various physiologic functions of the central nervous system (CNS). These …
development and various physiologic functions of the central nervous system (CNS). These …
Identifying miRNAs, targets and functions
Abstract microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the
universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs …
universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs …
MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
R Dai, SA Ahmed - Translational Research, 2011 - Elsevier
MicroRNAs (miRNAs) are newly discovered, small, noncoding ribonucleic acids (RNAs) that
play critical roles in the regulation of host genome expression at the posttranscriptional level …
play critical roles in the regulation of host genome expression at the posttranscriptional level …
Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure
M Lombardi, R Parolisi, F Scaroni, E Bonfanti… - Acta …, 2019 - Springer
Microglia are highly plastic immune cells which exist in a continuum of activation states. By
sha** the function of oligodendrocyte precursor cells (OPCs), the brain cells which …
sha** the function of oligodendrocyte precursor cells (OPCs), the brain cells which …
The role of miRNA in inflammation and autoimmunity
RP Singh, I Massachi, S Manickavel, S Singh… - Autoimmunity …, 2013 - Elsevier
Abstract miRNAs are small non-coding RNA molecules that modulate the expression of
multiple protein-encoding genes at the post-transcriptional level. They have recently been …
multiple protein-encoding genes at the post-transcriptional level. They have recently been …
IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats
DI Chen, BJ Dixon, DM Doycheva, B Li… - Journal of …, 2018 - Springer
Background The endoplasmic reticulum (ER) is responsible for the control of correct protein
folding and protein function which is crucial for cell survival. However, under pathological …
folding and protein function which is crucial for cell survival. However, under pathological …
Circulating microRNAs as biomarkers for disease staging in multiple sclerosis
Objective MicroRNAs (miRNAs) are single‐stranded, small noncoding RNAs that regulate
gene expression. Because they are stable in serum, they are being developed as …
gene expression. Because they are stable in serum, they are being developed as …
Biomarkers in multiple sclerosis
Substantial effort has been made over the last six decades to identify biomarkers for multiple
sclerosis that can improve disease diagnosis, predict disease progression, and improve …
sclerosis that can improve disease diagnosis, predict disease progression, and improve …