Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …

Copper is an important metal micronutrient, required for the balanced growth and normal
physiological functions of human organism. Copper-related toxicity and dysbalanced …

The ability to expand and activate natural Killer (NK) cells ex vivo has dramatically changed
the landscape in the development of novel adoptive cell therapies for treating cancer over …

Due to their intrinsic ability to eliminate malignant cells, natural killer (NK) cells emerge as a
promising immunotherapy for cancer. While clinical studies have affirmed the safety of NK …

Background Natural killer (NK) cells are cytotoxic cells capable of recognizing
heterogeneous cancer targets without prior sensitization, making them promising prospects …

Hepatocellular carcinoma (HCC), a major subtype of liver cancer, poses significant
therapeutic challenges due to its late diagnosis and rapid progression. The evolving …

Natural Killer (NK) cells are cytotoxic lymphocytes similar to group 1 of the innate lymphoid
cell (ILC1) family since they secrete interferon γ (IFNγ) and tumor necrosis factor (TNF) 1 In …

This thesis would not have been possible without the support of many brilliant individuals
who not only shaped me as a scientist but also contributed to my personal growth. The past …

Ex vivo gene-modified cellular immunotherapy, including chimeric antigen receptor (CAR)-T
and CAR-NK cell therapy, is a promising therapeutic modality for the treatment of various …