The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
Molecular mechanisms and cellular functions of cGAS–STING signalling
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
DNA sensing by the cGAS–STING pathway in health and disease
The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
The cytosolic DNA-sensing cGAS–STING pathway in cancer
The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved
mechanism to initiate rapid innate immune responses against microbial pathogens. The …
mechanism to initiate rapid innate immune responses against microbial pathogens. The …
Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
DNA damage and cancer immunotherapy: a STING in the tale
T Reisländer, FJ Groelly, M Tarsounas - Molecular cell, 2020 - cell.com
Cancer immunotherapies enhance anti-tumor immune responses using checkpoint
inhibitors, such as PD-1 or PD-L1 inhibitors. Recent studies, however, have extended the …
inhibitors, such as PD-1 or PD-L1 inhibitors. Recent studies, however, have extended the …
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
GP de Freitas Nader, S Agüera-Gonzalez, F Routet… - Cell, 2021 - cell.com
Although mutations leading to a compromised nuclear envelope cause diseases such as
muscular dystrophies or accelerated aging, the consequences of mechanically induced …
muscular dystrophies or accelerated aging, the consequences of mechanically induced …
Structural basis for sequestration and autoinhibition of cGAS by chromatin
Abstract Cyclic GMP–AMP synthase (cGAS) is an innate immune sensor for cytosolic
microbial DNA. After binding DNA, cGAS synthesizes the messenger 2′ 3′-cyclic GMP …
microbial DNA. After binding DNA, cGAS synthesizes the messenger 2′ 3′-cyclic GMP …
Structural basis for the inhibition of cGAS by nucleosomes
The cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) senses
invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and …
invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and …