Developmental mechanisms underlying the evolution of human cortical circuits
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
Evolution of the human nervous system function, structure, and development
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …
most distinctive and impressive attributes. How the nervous system has changed in the …
An atlas of the protein-coding genes in the human, pig, and mouse brain
INTRODUCTION The brain is the most complex organ of the mammalian body, boasting a
diverse physiology combined with intricate cellular organization. In an effort to expand our …
diverse physiology combined with intricate cellular organization. In an effort to expand our …
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of
primates that is centrally involved in cognition. We assessed more than 600,000 single …
primates that is centrally involved in cognition. We assessed more than 600,000 single …
Discovery of 42 genome-wide significant loci associated with dyslexia
Reading and writing are crucial life skills but roughly one in ten children are affected by
dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up …
dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up …
Genome-wide analyses of individual differences in quantitatively assessed reading-and language-related skills in up to 34,000 people
E Eising, N Mirza-Schreiber… - Proceedings of the …, 2022 - National Acad Sciences
The use of spoken and written language is a fundamental human capacity. Individual
differences in reading-and language-related skills are influenced by genetic variation, with …
differences in reading-and language-related skills are influenced by genetic variation, with …
Spatiotemporal transcriptomic divergence across human and macaque brain development
INTRODUCTION Improved understanding of how the develo** human nervous system
differs from that of closely related nonhuman primates is fundamental for teasing out human …
differs from that of closely related nonhuman primates is fundamental for teasing out human …
Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease
Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …
Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study
Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …
The genetic architecture and evolution of the human skeletal form
The human skeletal form underlies bipedalism, but the genetic basis of skeletal proportions
(SPs) is not well characterized. We applied deep-learning models to 31,221 x-rays from the …
(SPs) is not well characterized. We applied deep-learning models to 31,221 x-rays from the …