Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Over the past decade, compelling evidence has unveiled previously overlooked adaptive
characteristics of innate immune cells. Beyond their traditional role in providing short, non …

Traditionally, the innate and adaptive immune systems are differentiated by their specificity
and memory capacity. In recent years, however, this paradigm has shifted: Cells of the …

Innate immune cells can develop long-term memory after stimulation by microbial products
during infections or vaccinations. Here, we report that metabolic signals can induce trained …

Abstract Background The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases,
including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

Systemic autoinflammatory diseases (SAIDs) are a growing group of disorders caused by a
dysregulation of the innate immune system leading to episodes of systemic inflammation. In …

Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that
assembles inflammasome complexes in response to pathogen infections. Mutations in the …

The processing of pro-interleukin-1β depends on activation of caspase-1. Controversy has
arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of …

A syndrome of periodic fever that resembles human cyclic neutropenia in its clinical
presentation has been identified in 12 children observed at two major referral centers …