Biophysical interactions with model lipid membranes: applications in drug discovery and drug delivery
C Peetla, A Stine, V Labhasetwar - Molecular pharmaceutics, 2009 - ACS Publications
The transport of drugs or drug delivery systems across the cell membrane is a complex
biological process, often difficult to understand because of its dynamic nature. In this regard …
biological process, often difficult to understand because of its dynamic nature. In this regard …
Flexible macromolecules attached to lipid bilayers: impact on fluidity, curvature, permeability and stability of the membranes
C Tribet, F Vial - Soft Matter, 2008 - pubs.rsc.org
This review summarizes recent investigations on the association of macromolecules on lipid
bilayers. Hydrophilic and flexible polymers can form soft coronae tenuously adsorbed or …
bilayers. Hydrophilic and flexible polymers can form soft coronae tenuously adsorbed or …
Ultra-high capacity microfluidic trap** of giant vesicles for high-throughput membrane studies
N Yandrapalli, T Robinson - Lab on a Chip, 2019 - pubs.rsc.org
Biomimetic systems such as model lipid membranes are vital to many research fields
including synthetic biology, drug discovery and membrane biophysics. One of the most …
including synthetic biology, drug discovery and membrane biophysics. One of the most …
Interaction of tea catechin (—)-epigallocatechin gallate with lipid bilayers
A major component of green tea extracts, catechin (—)-Epigallocatechin gallate (EGCg), has
been reported to be biologically active and interacting with membranes. A recent study …
been reported to be biologically active and interacting with membranes. A recent study …
[HTML][HTML] Electric pulses induce cylindrical deformations on giant vesicles in salt solutions
In this article, we report for the first time unusual shape changes of vesicles subjected to
strong electric pulses in salt solutions of low concentration. The electric field is created by …
strong electric pulses in salt solutions of low concentration. The electric field is created by …
Asymmetric oxidation of giant vesicles triggers curvature-associated shape transition and permeabilization
J Heuvingh, S Bonneau - Biophysical journal, 2009 - cell.com
Oxidation of unsaturated lipids is a fundamental process involved in cell bioenergetics as
well as in cell death. Using giant unilamellar vesicles and a chlorin photosensitizer, we …
well as in cell death. Using giant unilamellar vesicles and a chlorin photosensitizer, we …
Action of antimicrobial peptides on bacterial and lipid membranes: a direct comparison
The bacterial membrane represents an attractive target for the design of new antibiotics to
combat widespread bacterial resistance. Understanding how antimicrobial peptides (AMPs) …
combat widespread bacterial resistance. Understanding how antimicrobial peptides (AMPs) …
Comparison of the effects of daptomycin on bacterial and model membranes
MT Lee, PY Yang, NE Charron, MH Hsieh… - Biochemistry, 2018 - ACS Publications
Daptomycin is a phosphatidylglycerol specific, calcium-dependent membrane-active
antibiotic that has been approved for the treatment of Gram-positive infections. A recent …
antibiotic that has been approved for the treatment of Gram-positive infections. A recent …
Lipid unsaturation properties govern the sensitivity of membranes to photoinduced oxidative stress
Unsaturated lipid oxidation is a fundamental process involved in different aspects of cellular
bioenergetics; dysregulation of lipid oxidation is often associated with cell aging and death …
bioenergetics; dysregulation of lipid oxidation is often associated with cell aging and death …
[HTML][HTML] Photo-dynamic induction of oxidative stress within cholesterol-containing membranes: shape transitions and permeabilization
R Kerdous, J Heuvingh, S Bonneau - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
Photochemical internalization is a drug delivery technology employing a photo-
destabilization of the endosomes and the photo-controlled release of endocyted …
destabilization of the endosomes and the photo-controlled release of endocyted …