Immunity to infection has been extensively studied in humans and mice bearing naturally
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …

Animals evolved in complex environments, producing a wide range of behaviors, including
navigation, foraging, prey capture, and conspecific interactions, which vary over timescales …

Laboratory mice, while paramount for understanding basic biological phenomena, are
limited in modeling complex diseases of humans and other free-living mammals. Because …

This Element presents a philosophical exploration of the concept of the'model organism'in
contemporary biology. Thinking about model organisms enables us to examine how living …

Non-alcoholic steatohepatitis (NASH) is a global health concern without treatment. The
challenge in finding effective therapies is due to the lack of good mouse models and the …

Only a limited number of animal species lend themselves to becoming model organisms in
multiple biological disciplines: one of these is the great pond snail, Lymnaea stagnalis …

Immunological Proteome Resource (ImmPRes; http://immpres. co. uk/). ImmPRes aims to
provide an in-depth high-quality map of the immune cell proteomes. It is an initiative inspired …

The laboratory rat was the first mammal domesticated for research purposes. It is descended
from wild Norway rats, Rattus norvegicus, which despite their name likely originated in Asia …

Identifying a common set of genes that mediate host–microbial interactions across
populations and species of mammals has broad relevance for human health and animal …

Wild populations of the house mouse (Mus musculus) represent the raw genetic material for
the classical inbred strains in biomedical research and are a major model system for …