CD28 costimulation: from mechanism to therapy
Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …
CD28-mediated co-stimulation: a quantitative support for TCR signalling
O Acuto, F Michel - Nature Reviews Immunology, 2003 - nature.com
The ability of naive T cells to clonally expand and acquire effector functions depends on the
strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory …
strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory …
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
Many functions of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) have
been defined, but relatively little is known about the biology of an alternative mTOR complex …
been defined, but relatively little is known about the biology of an alternative mTOR complex …
An enigmatic tail of CD28 signaling
JS Boomer, JM Green - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
CD28 costimulation regulates a wide range of cellular processes, from proliferation and
survival to promoting the differentiation of specialized T-cell subsets. Since first being …
survival to promoting the differentiation of specialized T-cell subsets. Since first being …
ISGylation–a key to lock the cell gates for preventing the spread of threats
C Villarroya-Beltri, S Guerra… - Journal of cell …, 2017 - journals.biologists.com
ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …
Antigen-receptor signaling to nuclear factor κB
J Schulze-Luehrmann, S Ghosh - Immunity, 2006 - cell.com
Signal transduction events leading to the survival, differentiation, or apoptosis of cells of the
innate or adaptive immune system must be properly coordinated to ensure the normal …
innate or adaptive immune system must be properly coordinated to ensure the normal …
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C θ translocation
T Yokosuka, W Kobayashi, K Sakata-Sogawa… - Immunity, 2008 - cell.com
T cell activation is mediated by microclusters (MCs) containing T cell receptors (TCRs),
kinases, and adaptors. Although TCR MCs translocate to form a central supramolecular …
kinases, and adaptors. Although TCR MCs translocate to form a central supramolecular …
T‐cell activation through immunological synapses and kinapses
ML Dustin - Immunological reviews, 2008 - Wiley Online Library
T‐cell activation requires 'contact'with antigen‐presenting cells (APCs) to bring the T‐cell
receptor (TCR) and antigenic major histocompatibility complex (MHC)‐peptide complex …
receptor (TCR) and antigenic major histocompatibility complex (MHC)‐peptide complex …
T cell antigen recognition and discrimination by electrochemiluminescence imaging
Adoptive T lymphocyte (T cell) transfer and tumour‐specific peptide vaccines are innovative
cancer therapies. An accurate assessment of the specific reactivity of T cell receptors (TCRs) …
cancer therapies. An accurate assessment of the specific reactivity of T cell receptors (TCRs) …
Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells
C Pfeifhofer, K Kofler, T Gruber… - The Journal of …, 2003 - rupress.org
Protein kinase C (PKC) θ is an established component of the immunological synapse and
has been implicated in the control of AP-1 and NF-κB. To study the physiological function of …
has been implicated in the control of AP-1 and NF-κB. To study the physiological function of …