Aims Chronic kidney disease (CKD) and worsening renal function (WRF) have been
associated with poor outcome in heart failure (HF). Methods and results Articles were …

With a prevalence of 5.8 million in the United States alone, heart failure (HF) is associated
with high morbidity, mortality, and healthcare expenditures. Close to 1 million …

Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure
with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction …

Acute decompensated heart failure (ADHF) is one of the leading admission diagnoses
worldwide, yet it is an entity with incompletely understood pathophysiology and limited …

Aims Signs and symptoms of congestion are the most common cause for hospitalization for
heart failure (HHF). The clinical course and prognostic value of congestion during HHF has …

AKI associates with increased long-term risk of mortality, but the prognostic significance of
AKI in terms of long-term cardiovascular disease remains unconfirmed. We conducted a …

Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked
increases in death and rehospitalization rates, which then decline exponentially though they …

Renal dysfunction is common in patients with heart failure and is associated with high
morbidity and mortality. Cardiac and renal dysfunction may worsen each other through …

Endpoint selection is a critically important step in clinical trial design. It poses major
challenges for investigators, regulators, and study sponsors, and it also has important …

Background: In patients with acute heart failure (AHF), dyspnea relief is the most immediate
goal. Renal dysfunction, diuretic resistance, and hyponatremia represent treatment …