Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Over the last 4 decades, cell culture techniques have evolved towards the creation of in vitro
multicellular entities that incorporate the three-dimensional complexity of in vivo tissues and …

Organoids, which exhibit spontaneous organ specific organization, function, and multi-
cellular complexity, are in essence the in vitro reproduction of specific in vivo organ systems …

Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1
Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation …

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as
diabetes treatment. Despite recent progress, efforts to generate physiologically competent β …

Encapsulation of donor islets using a hydrogel material is a well-studied strategy for islet
transplantation, which protects donor islets from the host immune response. Replacement of …

Differentiation of stem cells into functional replacement cells and tissues is a major goal of
the regenerative medicine field. However, one limitation has been organization of …

The term vascular niche indicate the physical and biochemical microenvironment around
blood vessel where endothelial cells, pericytes, and smooth muscle cells organize …

Pancreatic islets are densely packed cellular aggregates containing various hormonal cell
types essential for blood glucose regulation. Interactions among these cells markedly affect …

Organoids can be regarded as a beneficial tool for discovery of new therapeutics for
diabetes and/or maturation of pancreatic progenitors (PP) towards β cells. Here, we devised …