MicroRNAs: from mechanism to organism

PJ Dexheimer, L Cochella - Frontiers in cell and developmental …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

Small and long non-coding RNAs: Past, present, and future

LL Chen, VN Kim - Cell, 2024 - cell.com
Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

An integrated expression atlas of miRNAs and their promoters in human and mouse

D De Rie, I Abugessaisa, T Alam, E Arner, P Arner… - Nature …, 2017 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As
part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) …

The molecular evolution of spermatogenesis across mammals

F Murat, N Mbengue, SB Winge, T Trefzer, E Leushkin… - Nature, 2023 - nature.com
The testis produces gametes through spermatogenesis and evolves rapidly at both the
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …

Structural and functional basis of mammalian microRNA biogenesis by Dicer

D Zapletal, E Taborska, J Pasulka, R Malik, K Kubicek… - Molecular cell, 2022 - cell.com
MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by
Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs

E Londin, P Loher, AG Telonis… - Proceedings of the …, 2015 - National Acad Sciences
Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …

A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome

B Fromm, T Billipp, LE Peck, M Johansen… - Annual review of …, 2015 - annualreviews.org
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …

Comparative transcriptomics in human and mouse

A Breschi, TR Gingeras, R Guigó - Nature Reviews Genetics, 2017 - nature.com
Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

The roles of microRNAs in mouse development

B DeVeale, J Swindlehurst-Chan… - Nature Reviews Genetics, 2021 - nature.com
Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns
during embryonic and postnatal mouse development. The loss of all miRNAs through the …

A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription

L **, Q Tang, S Hu, Z Chen, X Zhou, B Zeng… - Nature …, 2021 - nature.com
A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding of
tissue specialization processes underlying economically valuable traits and accelerate their …