Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

The status of the human gene catalogue

P Amaral, S Carbonell-Sala, FM De La Vega, T Faial… - Nature, 2023 - nature.com
Scientists have been trying to identify every gene in the human genome since the initial draft
was published in 2001. In the years since, much progress has been made in identifying …

The ProteomeXchange consortium at 10 years: 2023 update

EW Deutsch, N Bandeira, Y Perez-Riverol… - Nucleic acids …, 2023 - academic.oup.com
Mass spectrometry (MS) is by far the most used experimental approach in high-throughput
proteomics. The ProteomeXchange (PX) consortium of proteomics resources (http://www …

The ProteomeXchange consortium in 2020: enabling 'big data'approaches in proteomics

EW Deutsch, N Bandeira, V Sharma… - Nucleic acids …, 2020 - academic.oup.com
The ProteomeXchange (PX) consortium of proteomics resources (http://www.
proteomexchange. org) has standardized data submission and dissemination of mass …

NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants

L Zhao, J Wang, Y Li, T Song, Y Wu, S Fang… - Nucleic acids …, 2021 - academic.oup.com
Abstract NONCODE (http://www. noncode. org/) is a comprehensive database of collection
and annotation of noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals …

Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty

C Badowski, B He, LX Garmire - NPJ precision oncology, 2022 - nature.com
Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

RNAcentral 2021: secondary structure integration, improved sequence search and new member databases

Nucleic acids research, 2021 - academic.oup.com
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that
provides a single access point to 44 RNA resources and> 18 million ncRNA sequences from …

The how and why of lncRNA function: an innate immune perspective

EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

The functions and unique features of LncRNAs in cancer development and tumorigenesis

K Taniue, N Akimitsu - International journal of molecular sciences, 2021 - mdpi.com
Over the past decades, research on cancer biology has focused on the involvement of
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …

From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo

D Andergassen, JL Rinn - Nature Reviews Genetics, 2022 - nature.com
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …