Effects of oxysterols on immune cells and related diseases

FA de Freitas, D Levy, CO Reichert, E Cunha-Neto… - Cells, 2022 - mdpi.com
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on
several cells, organs, and systems in the body. Oxysterols also have an influence on the …

Oxysterols are potential physiological regulators of ageing

P de Medina, S Silvente-Poirot, M Poirot - Ageing Research Reviews, 2022 - Elsevier
Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol-and 7β-hydroxycholesterol …

L Rezig, I Ghzaiel, M Ksila, A Yammine, T Nury… - Steroids, 2022 - Elsevier
ketocholesterol and 7β-hydroxycholesterol are two oxysterols mainly formed by the
autoxidation of cholesterol. These two molecules are interconvertible via specific enzymes …

Dietary cholesterol oxidation products: Perspectives linking food processing and storage with health implications

Y Liu, X Yang, F **ao, F Jie, Q Zhang… - … Reviews in Food …, 2022 - Wiley Online Library
Dietary cholesterol oxidation products (COPs) are heterogeneous compounds formed
during the processing and storage of cholesterol‐rich foods, such as seafood, meat, eggs …

Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications

I Ghzaiel, K Sassi, A Zarrouk, S Ghosh… - Redox …, 2022 - rem.bioscientifica.com
Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol
essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the …

Lipids associated with autophagy: Mechanisms and therapeutic targets

M Jarocki, K Turek, J Saczko, M Tarek… - Cell Death Discovery, 2024 - nature.com
Autophagy is a molecular process essential for maintaining cellular homeostasis, with its
impairment or dysregulation linked to the progression of various diseases in mammals …

25-hydroxycholesterol in health and diseases

C Nguyen, J Saint-Pol, S Dib, C Pot, F Gosselet - Journal of Lipid Research, 2024 - ASBMB
Cholesterol is an essential structural component of all membranes of mammalian cells
where it plays a fundamental role not only in cellular architecture, but also, for example, in …

7-Ketocholesterol induces oxiapoptophagy and inhibits osteogenic differentiation in MC3T3-E1 Cells

J Ouyang, Y **ao, Q Ren, J Huang, Q Zhou, S Zhang… - Cells, 2022 - mdpi.com
7-Ketocholesterol (7KC) is one of the oxysterols produced by the auto-oxidation of
cholesterol during the dysregulation of cholesterol metabolism which has been implicated in …

The impacts of cholesterol, oxysterols, and cholesterol lowering dietary compounds on the immune system

R Yanagisawa, C He, A Asai, M Hellwig… - International Journal of …, 2022 - mdpi.com
Cholesterol and its oxidized forms, oxysterols, are ingested from foods and are synthesized
de novo. Cholesterol and oxysterols influence molecular and cellular events and …

Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 …

I Ghzaiel, A Zarrouk, S Essadek, L Martine… - Steroids, 2022 - Elsevier
Peroxisomes play an important role in regulating cell metabolism and RedOx homeostasis.
Peroxisomal dysfunctions favor oxidative stress and cell death. The ability of 7β …