Copper is a ubiquitous element in the environment as well as living organisms, with its redox
capabilities and complexation potential making it indispensable for many cellular functions …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

Decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1), a vital enzyme for cell wall
synthesis, plays a crucial role in the formation of lipoarabinomannan and arabinogalactan. It …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

New classes of drugs are needed to treat tuberculosis (TB) in order to combat the
emergence of resistance (MDR and XDR) to existing agents and shorten the duration of …

The recent past has experienced a renaissance in tuberculosis (TB) research. New
molecular biology reagents and genetic tools have been developed and whole genome …

The global burden of tuberculosis, its health and socio-economic impacts, the presence of
drug-resistant forms and a potential threat of latent tuberculosis should serve as a strong …

Thiazoles are important heterocyclics exhibiting boundaryless biological activities, such as
antibacterial, antifungal, anti-inflammatory, antitumor, antitubercular, antidiabetic, antiviral …

Latent tuberculosis infection (LTBI) represents a major challenge to curing TB disease.
Current guidelines for LTBI management include only three older drugs and their …