Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …
contemporary drug discovery programmes and present a number of challenges to drug …
[BOOK][B] Food emulsions: principles, practices, and techniques
DJ McClements - 2004 - taylorfrancis.com
Food Emulsions: Principles, Practice, and Techniques, Second Edition introduces the
fundamentals of emulsion science and demonstrates how this knowledge can be applied to …
fundamentals of emulsion science and demonstrates how this knowledge can be applied to …
[HTML][HTML] Biophysical insights into modulating lipid digestion in food emulsions
During the last decade, major scientific advances on understanding the mechanisms of lipid
digestion and metabolism have been made, with a view to addressing health issues (such …
digestion and metabolism have been made, with a view to addressing health issues (such …
50 years of oral lipid-based formulations: provenance, progress and future perspectives
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
Research progress on liposomes: Application in food, digestion behavior and absorption mechanism
W Liu, Y Hou, Y **, Y Wang, X Xu, J Han - Trends in Food Science & …, 2020 - Elsevier
Background The application of liposomal system in food area allowing carried and
controlled bioactive-molecules release has been considered one of the main strategies …
controlled bioactive-molecules release has been considered one of the main strategies …
Enhancing intestinal drug solubilisation using lipid-based delivery systems
Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …
Self-Assembly of block copolymers into internally ordered microparticles
Block copolymer (BCP) self-assembly is one of the most versatile concepts for the bottom-up
design of functional nanostructures in materials science, nanomedicine and …
design of functional nanostructures in materials science, nanomedicine and …
Oral lipid-based formulations
DJ Hauss - Advanced drug delivery reviews, 2007 - Elsevier
Poor drug solubility remains a significant and frequently encountered problem for
pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal …
pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal …
Review of in vitro digestion models for rapid screening of emulsion-based systems
DJ McClements, Y Li - Food & function, 2010 - pubs.rsc.org
There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …