Ghrelin was discovered in 1999 as the endogenous ligand of the growth-hormone
secretagogue receptor 1a (GHSR1a). Since then, ghrelin has been found to exert a plethora …

Obesity is a significant contemporary health concern that carries wide-ranging implications
for society, as well as for individual health and well-being. In particular, the …

Traditional models of appetite control have emphasised the role of parallel homeostatic and
hedonic systems, but more recently the distinction between independent homeostatic and …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (Aβ) causes …

Ghrelin is a 28-amino-acid peptide hormone, first described in 1999 and broadly expressed
in the organism. As the only known orexigenic hormone secreted in the periphery, it …

Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

Although often referred to as a hunger hormone, recent evidence highlights a
neuroprotective function of acylated ghrelin (AG) and a substantial role in the regulation of …

Ghrelin acts as a neuropeptide. It participates in sleep–wake regulation. After systemic
ghrelin treatment nonREM sleep is promoted in male humans and mice. This effect is …

Ghrelin, an orexigenic brain-gut hormone promoting feeding and regulating energy
metabolism in human and rodents, was reported to enhance both adult neurogenesis and …

Background and Purpose Bariatric surgery is associated with improved cognitive function,
but the mechanisms underlying these gains remain poorly understood. Disturbed leptin and …