Systemic antiplatelet treatment represents a promising option to improve the therapeutic
outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical …

Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …

Because metastasis is associated with the majority of cancer-related deaths, its prevention is
a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the …

The primary hemostatic function of platelets has been recognized for more than a century,
but increasing experimental and clinical evidences suggest that platelets are also important …

Extensive experimental evidence indicates that platelets contribute to tumor cell proliferation
and metastasis through direct interactions and secreted bioactive proteins. Activated …

Until recently, the nucleic acid content of platelets was considered to be fully determined by
their progenitor megakaryocyte. However, it is now well understood that additional …

Platelets promote metastasis, however, their role in tumor growth remains controversial.
Here, we investigated the effect of platelet interactions with colorectal tumor cells. Platelets …

The platelet P2Y12 receptor (P2Y12R) for adenosine 5′ diphosphate (ADP) plays a central
role in platelet function, hemostasis, and thrombosis. Patients with inherited P2Y12R defects …

The growing insights in the complex interactions between metastatic cancer-cells and
platelets have revealed that platelet tumor cell interactions in the blood stream are an …