Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically
acquired damage to genes that directly regulate their cell cycles. Genetic alterations …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

Our recent work has shown that activation of the Ras/Raf/ERK pathway extends the half-life
of the Myc protein and thus enhances the accumulation of Myc activity. We have extended …

Summary The Cdk-Rb-E2F pathway integrates external and internal signals to control
progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway …

Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …

We have previously shown that the persistent activation of p42/p44 MAPK is required to
pass the G 1 restriction point in fibroblasts (Pagès, G., Lenormand, P., L'Allemain, G …

Progression through G1/S phase of the cell cycle is coordinated by cyclin-dependent kinase
(CDK) activities. Here, we find that the requirement for different CDK activities and cyclins in …

Diploid and stable karyotypes are associated with health and fitness in animals. By contrast,
whole-genome duplications—doublings of the entire complement of chromosomes—are …

Cell cycle progression is regulated by a wide variety of external factors, amongst them are
growth factors and extracellular matrix factors. During the last decades evidence has been …

Abstract The E2 factor (E2F) family of transcription factors are downstream targets of the
retinoblastoma protein. E2F factors have been known for several years to be important …