Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
Tissue homeostasis and inflammation
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …
inflammation. However, despite an abundance of data, the organizing principles of tissue …
[HTML][HTML] Role of prostaglandin E2 in tissue repair and regeneration
Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …
Use of zebrafish in drug discovery toxicology
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …
health and money. The drug discovery industry attempts to minimize those events with …
Identification of environmental factors that promote intestinal inflammation
Genome-wide association studies have identified risk loci linked to inflammatory bowel
disease (IBD)—a complex chronic inflammatory disorder of the gastrointestinal tract. The …
disease (IBD)—a complex chronic inflammatory disorder of the gastrointestinal tract. The …
Zebrafish as tools for drug discovery
The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …
contributed to several examples of successful phenotype-based drug discovery. For the …
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
INTRODUCTION Currently there are no approved treatments for sarcopenia, the age-
dependent loss of skeletal muscle mass and strength that constitutes a major public health …
dependent loss of skeletal muscle mass and strength that constitutes a major public health …
Angiocrine functions of organ-specific endothelial cells
Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …
Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy
Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …
[HTML][HTML] Hematopoietic stem cell metabolism during development and aging
Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …