Although it was long thought that eukaryotic translation almost always initiates at an AUG
start codon, recent advancements in ribosome footprint map** have revealed that non …

This review summarizes our current understanding of the major pathway for the initiation
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …

Translation initiation in eukaryotes is a highly regulated and complex stage of gene
expression. It requires the action of at least 12 initiation factors, many of which are known to …

This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …

During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are
largely determined by substrate availability, amino acid features and reaction kinetics …

Viruses are fully reliant on the translation machinery of their host cells to produce the
polypeptides that are essential for viral replication. Consequently, viruses recruit host …

Translational control plays an essential role in the regulation of gene expression. It is
especially important in defining the proteome, maintaining homeostasis, and controlling cell …

Viruses must co-opt the cellular translation machinery to produce progeny virions.
Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation …

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has
received increased attention during recent years due to its emerging significance for many …

Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions.
This can be achieved by the phosphorylation-mediated inactivation of a key translation …