In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

The Cas9 protein (CRISPR-associated protein 9), derived from type II CRISPR (clustered
regularly interspaced short palindromic repeats) bacterial immune systems, is emerging as a …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Large-scale chromosome structure and spatial nuclear arrangement have been linked to
control of gene expression and DNA replication and repair. Genomic techniques based on …

RNA-guided Cas9 nucleases derived from clustered regularly interspaced short palindromic
repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the …

Understanding the topological configurations of chromatin may reveal valuable insights into
how the genome and epigenome act in concert to control cell fate during development …

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few
blood cells that truly age,. Paradoxically, although HSCs numerically expand with age, their …

Chromosomes are the physical realization of genetic information and thus form the basis for
its readout and propagation. Here we present a high-resolution chromosomal contact map …

The spatial organization of the genome plays an important role in the regulation of gene
expression. However, the core structural features of animal genomes, such as topologically …

Epigenetic pathways are essential in different biological processes and in phenotype-
environment interactions in response to different stressors and they can induce phenotypic …