In contrast to the major families of small molecules and antibodies, cyclic peptides, as a
family of synthesizable macromolecules, have distinct biochemical and therapeutic …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Solvent shielding of the amide hydrogen bond donor (NH groups) through chemical
modification or conformational control has been successfully utilized to impart membrane …

Protein-protein interactions (PPIs) are well-established as a class of promising drug targets
for their implications in a wide range of biological processes. However, drug development …

Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …

Peptides have traditionally been perceived as poor drug candidates due to unfavorable
characteristics mainly regarding their pharmacokinetic behavior, including plasma stability …

The growing prevalence of resistance to antibiotics motivates the search for new
antibacterial agents. Antimicrobial peptides are a diverse class of well-studied membrane …

One of the ultimate goals of analytic chemistry is to efficiently discriminate between amino
acids. Here we demonstrate this ability using a single-molecule electrical methodology …

Phage display was first described by George P. Smith when it was shown that virus particles
were capable of presenting foreign proteins on their surface. The technology has paved the …

Technological advances and breakthrough developments in the pharmaceutical field are
knocking at the door of the “undruggable” fortress with increasing insistence. Notably, the …