Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health
issues and financial strain for patients. Traditional treatments for IVDD can alleviate pain but …

Small interfering RNAs (siRNAs) indicate the unprecedented versatility in silencing disease-
causing genes. However, the therapeutic use of siRNA is limited by its inherent instability in …

Gene therapeutics including siRNAs, anti‐sense oligos, messenger RNAs, and CRISPR
ribonucleoprotein complexes offer unmet potential to treat over 7,000 known genetic …

Neurodegenerative disorders (NDs) are becoming one of the leading causes of disability
and death across the globe due to lack of timely preventions and treatments. Concurrently …

Abstract Poly (lactide-co-glycolide)-cholesterol (PLGA-C)-based nanoparticles (NPs) were
developed for the tumor-targeted delivery of curcumin (CUR). PLGA-C/CUR NPs with∼ 200 …

The characteristic features of diabetic nephropathy include thickening of the glomerular
basement membranes, expansion of mesangium, and appearance of albumin in the urine …

BACKGROUND CONTEXT One of the common causes of low back pain is intervertebral
disc degeneration. The pathophysiology of disc degeneration involves apoptosis of nucleus …

Although efforts have been made to develop a platform carrier for the delivery of RNAi
therapeutics, systemic delivery of siRNA has shown only limited success in cancer therapy …

Aim: To investigate the efficacy of lactoferrin nanoparticles (LfNPs) in delivering siRNA
across the blood–brain barrier to treat glioblastoma multiforme (GBM) and with an additional …

Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in the
Western population, claiming 17000 deaths per year in the United States and affecting 25 …