Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
Basic concepts of epigenetics: impact of environmental signals on gene expression
EA Mazzio, KFA Soliman - Epigenetics, 2012 - Taylor & Francis
Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …
DNA damage in neurodegenerative diseases
F Coppedè, L Migliore - Mutation Research/Fundamental and Molecular …, 2015 - Elsevier
Following the observation of increased oxidative DNA damage in nuclear and mitochondrial
DNA extracted from post-mortem brain regions of patients affected by neurodegenerative …
DNA extracted from post-mortem brain regions of patients affected by neurodegenerative …
Accumulated hippocampal formaldehyde induces age-dependent memory decline
Z Tong, C Han, W Luo, X Wang, H Li, H Luo, J Zhou… - Age, 2013 - Springer
Aging is an important factor in memory decline in aged animals and humans and in
Alzheimer's disease and is associated with the impairment of hippocampal long-term …
Alzheimer's disease and is associated with the impairment of hippocampal long-term …
Genetics and epigenetics of Parkinson′ s disease
F Coppedè - The Scientific World Journal, 2012 - Wiley Online Library
In 1997 a mutation in the a-synuclein (SNCA) gene was associated with familial autosomal
dominant Parkinson's disease (PD). Since then, several loci (PARK1‐15) and genes have …
dominant Parkinson's disease (PD). Since then, several loci (PARK1‐15) and genes have …
Epigenetic mechanisms in Parkinson's disease
Y Feng, J Jankovic, YC Wu - Journal of the neurological sciences, 2015 - Elsevier
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD …
disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD …
Genotoxic and epigenetic mechanisms in arsenic carcinogenicity
Arsenic is a human carcinogen with weak mutagenic properties that induces tumors through
mechanisms not yet completely understood. People worldwide are exposed to arsenic …
mechanisms not yet completely understood. People worldwide are exposed to arsenic …
Epigenetics of aging and Alzheimer's disease: Implications for pharmacogenomics and drug response
R Cacabelos, C Torrellas - International journal of molecular sciences, 2015 - mdpi.com
Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA
regulation) is common in physiological and pathological conditions. Epigenetic alterations …
regulation) is common in physiological and pathological conditions. Epigenetic alterations …
Association of micronucleus frequency with neurodegenerative diseases
Micronuclei (MNi) can originate either from chromosome breakage or chromosome
malsegregation events and are therefore ideal biomarkers to investigate genomic instability …
malsegregation events and are therefore ideal biomarkers to investigate genomic instability …
Genome instability in Alzheimer disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia. Autosomal dominant, familial AD (fAD) is very rare and caused …
common form of dementia. Autosomal dominant, familial AD (fAD) is very rare and caused …