Increases in cytosolic free Ca2+ ([Ca2+] i) represent a ubiquitous signalling mechanism that
controls a variety of cellular processes, including proliferation, metabolism and gene …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Ubiquitously expressed micro-and millicalpain, which both require the calpain small 1
(CAPNS1) regulatory subunit for function, play important roles in numerous biological and …

Photoreceptor degeneration in retinitis pigmentosa is one of the leading causes of
hereditary blindness in the developed world. Although causative genetic mutations have …

The retinal degeneration (rd) 1 mouse displays an inherited retinal degeneration and
therefore allows studies of the molecular mechanisms behind the blinding disease retinitis …

We have analyzed the molecular mechanisms of photoinduced cell death using porphyrins
with similar structure differing only in the position of the ethylene glycol (EG) chain on the …

Maintenance of cellular homeostasis requires tight and coordinated control of numerous
metabolic pathways, which are governed by interconnected networks of signaling pathways …

Nitric oxide and reactive oxygen species play a critical role in photoreceptor apoptosis.
However, the exact molecular mechanisms triggered by oxidative stress in photoreceptor …

Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease
characterized by cell-cell detachment within the stratified epithelium (acantholysis) caused …