The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …

Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Review on the time-dependent recruitment of inflammatory cells and unanswered questions
regarding inflammatory cells in the pathophysiology of ischemic stroke. Inflammation plays …

Background: The healthy vascular endothelium, which forms the barrier between blood and
the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and …

The immune response to ischemic stroke is an area of study that is at the forefront of stroke
research and presents promising new avenues for treatment development. Upon cerebral …

Background and Purpose—Collaterals sustain the penumbra before recanalization and
offset infarct growth, yet the influence of baseline collateral flow on recanalization after …

Recent work on glial cell physiology has revealed that glial cells, and astrocytes in
particular, are much more actively involved in brain information processing than previously …

The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …

Ischemic stroke is a leading cause of disability worldwide. In cerebral ischemia there is an
enhanced expression of matrix metallo-proteinase-9 (MMP-9), which has been associated …