Biology and therapeutic targeting of vascular endothelial growth factor A
L Pérez-Gutiérrez, N Ferrara - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …
process in which several families of regulators have been implicated. Among these, vascular …
Pathological angiogenesis: mechanisms and therapeutic strategies
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …
existing ones, is an essential process for growth and development. Different mechanisms …
[HTML][HTML] Manganese ferrite (MnFe2O4) nanostructures for cancer theranostics
Over the past decade, transition metal-based ferrite nanostructures, displaying MFe 2 O 4
stoichiometry (M 2+ cations, eg, Mn, Co, Ni and Zn), have been devised and examined …
stoichiometry (M 2+ cations, eg, Mn, Co, Ni and Zn), have been devised and examined …
[HTML][HTML] The impact of VEGF on cancer metastasis and systemic disease
Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial …
other blood-borne substances and, in certain settings, also for the provision of endothelial …
Mechanisms of cancer metastasis
Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …
Tissue homeostasis and inflammation
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …
inflammation. However, despite an abundance of data, the organizing principles of tissue …
Milestones in tumor vascularization and its therapeutic targeting
Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …
launched more than 50 years ago with the proposition and experimental demonstrations that …
Age-related macular degeneration
Age-related macular degeneration is a leading cause of visual impairment and severe vision
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …
Smart bioadhesives for wound healing and closure
The high demand for rapid wound healing has spurred the development of multifunctional
and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing …
and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing …