In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer
membrane that plays a key role in host–pathogen interactions with the innate immune …

Biofilms are a predominant form of growth for bacteria in the environment and in the clinic.
Critical for biofilm development are adherence, proliferation, and dispersion phases. Each of …

SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …

In previous work (EE Smith, DG Buckley, Z. Wu, C. Saenphimmachack, LR Hoffman, DA
D'Argenio, SI Miller, BW Ramsey, DP Speert, SM Moskowitz, JL Burns, R. Kaul, and MV …

Hypermutable or mutator microorganisms are those that have an increased spontaneous
mutation rate as a result of defects in DNA repair or error avoidance systems. Over the last …

Bacteria are social organisms that commonly live in dense communities surrounded by a
multitude of other species. The competitive and cooperative interactions between these …

During the chronic lung infection of patients with cystic fibrosis (CF), Pseudomonas
aeruginosa can survive for long periods due to adaptive evolution mediated by genetic …

Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …

The advent of high-throughput sequencing techniques has made it possible to follow the
genomic evolution of pathogenic bacteria by comparing longitudinally collected bacteria …