Background Prostate cancer tissues are inherently heterogeneous, which presents a
challenge for metabolic profiling using traditional bulk analysis methods that produce an …

Over the past 30 years, continuous progress in the application of nuclear magnetic
resonance (NMR) spectroscopy and magnetic resonance spectroscopic imaging (MRSI) to …

Separating indolent from aggressive prostate cancer is an important clinical challenge for
identifying patients eligible for active surveillance, thereby reducing the risk of overtreatment …

According to World Health Organization (WHO) estimates, cancer is responsible for more
deaths than all coronary heart disease or stroke worldwide, serving as a major public health …

Reactive stroma is a tissue feature commonly observed in the tumor microenvironment of
prostate cancer and has previously been associated with more aggressive tumors. The aim …

Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic
prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been …

Introduction Preeclampsia is a heterogeneous gestational disease characterized by
maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is …

Levels of zinc, along with its mechanistically related metabolites citrate and aspartate, are
widely reported as reduced in prostate cancer compared to healthy tissue and are therefore …

Purpose: Low concentrations of citrate and high concentrations of choline-containing
compounds (ChoCC) are metabolic characteristics observed by magnetic resonance …

Background: Robust biomarkers that identify prostate cancer patients with high risk of
recurrence will improve personalised cancer care. In this study, we investigated whether …