Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model
system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties …

The endothelial barrier maintains vascular and tissue homeostasis and modulates many
physiological processes, such as angiogenesis. Vascular barrier integrity can be disrupted …

Background and Purpose—FTY720 is a known sphingosine 1–phosphate receptor agonist.
In the present study, we investigated the neuroprotective effect of postischemic …

The five known members of the sphingosine-1-phosphate (S1P) receptor family exhibit
diverse tissue expression profiles and couple to distinct G-protein-mediated signalling …

Sphingolipids are a structural component of the cell membrane, derived from sphingosine,
an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations …

Congenital long QT syndrome (LQTS) is a hereditary disorder that leads to sudden cardiac
death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been …

The sphingosine kinases 1 and 2 (SphK1 and 2) catalyze the phosphorylation of the lipid,
sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P). The …

Abstract Sphingosine-1-phosphate (S1P) has gained special attention in the high-density
lipoprotein (HDL) field because HDL is the most prominent plasma carrier of S1P and …

G protein-coupled receptors signal through a variety of mechanisms that impact cardiac
function, including contractility and hypertrophy. G protein–dependent and G protein …