Unveiling the mechanisms and challenges of cancer drug resistance

SU Khan, K Fatima, S Aisha, F Malik - Cell Communication and Signaling, 2024 - Springer
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy

L Yang, A Li, Y Wang, Y Zhang - Signal Transduction and Targeted …, 2023 - nature.com
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

Managing the TME to improve the efficacy of cancer therapy

MT Bilotta, A Antignani, DJ Fitzgerald - Frontiers in immunology, 2022 - frontiersin.org
The tumor microenvironment (TME) influences tumor growth, metastatic spread and
response to treatment. Often immunosuppression, mediated by the TME, impairs a beneficial …

[HTML][HTML] Apoptosis deregulation and the development of cancer multi-drug resistance

CM Neophytou, IP Trougakos, N Erin, P Papageorgis - Cancers, 2021 - mdpi.com
Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

[HTML][HTML] Targeting the tumor microenvironment: Potential strategy for cancer therapeutics

Q Babar, A Saeed, TA Tabish, M Sarwar… - Biochimica et Biophysica …, 2023 - Elsevier
Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

Unraveling the tumor microenvironment: Insights into cancer metastasis and therapeutic strategies

M El-Tanani, SA Rabbani, R Babiker, I Rangraze… - Cancer Letters, 2024 - Elsevier
This comprehensive review delves into the pivotal role of the tumor microenvironment (TME)
in cancer metastasis and therapeutic response, offering fresh insights into the intricate …

Role of hypoxia in the tumor microenvironment and targeted therapy

G Chen, K Wu, H Li, D **a, T He - Frontiers in oncology, 2022 - frontiersin.org
Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer

A Podolski-Renić, AČ Gašparović, A Valente… - European Journal of …, 2024 - Elsevier
Overcoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In
this respect, Schiff base-related compounds (bearing a R 1 R 2 Cdouble bondNR 3 bond) …

[HTML][HTML] Innovative strategies for photodynamic therapy against hypoxic tumor

X Li, L Chen, M Huang, S Zeng, J Zheng, S Peng… - Asian journal of …, 2023 - Elsevier
Photodynamic therapy (PDT) is applied as a robust therapeutic option for tumor, which
exhibits some advantages of unique selectivity and irreversible damage to tumor cells …

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy

B Song, P Yang, S Zhang - Cancer communications, 2024 - Wiley Online Library
Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …