[HTML][HTML] On the human taste perception: Molecular-level understanding empowered by computational methods
Background The perception of taste is a prime example of complex signal transduction at the
subcellular level, involving an intricate network of molecular machinery, which can be …
subcellular level, involving an intricate network of molecular machinery, which can be …
An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety
Artificial sweeteners have become increasingly popular worldwide owing to their lower
calorie content in addition to the claims of health benefits such as weight control, blood …
calorie content in addition to the claims of health benefits such as weight control, blood …
Structural basis for perception of diverse chemical substances by T1r taste receptors
The taste receptor type 1 (T1r) family perceives 'palatable'tastes. These receptors function as
T1r2-T1r3 and T1r1-T1r3 heterodimers to recognize a wide array of sweet and umami …
T1r2-T1r3 and T1r1-T1r3 heterodimers to recognize a wide array of sweet and umami …
Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments
S Hao, B Guthrie, SK Kim, S Balanda… - Communications …, 2024 - nature.com
Sucrose provides both sweetness and energy by binding to both Venus flytrap domains
(VFD) of the heterodimeric sweet taste receptor (T1R2/T1R3). In contrast, non-caloric …
(VFD) of the heterodimeric sweet taste receptor (T1R2/T1R3). In contrast, non-caloric …
Interkingdom detection of bacterial quorum-sensing molecules by mammalian taste receptors
YI Kouakou, RJ Lee - Microorganisms, 2023 - mdpi.com
Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively)
were originally identified in type II taste cells on the tongue, where they signal perception of …
were originally identified in type II taste cells on the tongue, where they signal perception of …
Bitter and sweet tasting molecules: It's complicated
Abstract “Bitter” and “sweet” are frequently framed in opposition, both functionally and
metaphorically, in regard to affective responses, emotion, and nutrition. This oppositional …
metaphorically, in regard to affective responses, emotion, and nutrition. This oppositional …
The cephalic phase insulin response to nutritive and low-calorie sweeteners in solid and beverage form
The purpose of the study was to examine the role of the cephalic phase insulin response
(CPIR) following exposure to nutritive and low-calorie sweeteners in solid and beverage …
(CPIR) following exposure to nutritive and low-calorie sweeteners in solid and beverage …
Binding hotspot and activation mechanism of maltitol and lactitol toward the human sweet taste receptor
Human sweet taste receptor (hSTR) recognizes a wide array of sweeteners, resulting in
sweet taste perception. Maltitol and lactitol have been extensively used in place of sucrose …
sweet taste perception. Maltitol and lactitol have been extensively used in place of sucrose …
Biophysical and functional characterization of the human TAS1R2 sweet taste receptor overexpressed in a HEK293S inducible cell line
Sweet taste perception is mediated by a heterodimeric receptor formed by the assembly of
the TAS1R2 and TAS1R3 subunits. TAS1R2 and TAS1R3 are class C G-protein-coupled …
the TAS1R2 and TAS1R3 subunits. TAS1R2 and TAS1R3 are class C G-protein-coupled …
Atomistic mechanisms underlying the activation of the G protein-coupled sweet receptor heterodimer by sugar alcohol recognition
Abstract The human T1R2-T1R3 sweet taste receptor (STR) plays an important role in
recognizing various low-molecular-weight sweet-tasting sugars and proteins, resulting in the …
recognizing various low-molecular-weight sweet-tasting sugars and proteins, resulting in the …